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arXiv · 2010.04757

Predictive Modeling of Anatomy with Genetic and Clinical Data

Adrian V. Dalca·Ramesh Sridharan·Mert R. Sabuncu·Polina Golland
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Abstract

We present a semi-parametric generative model for predicting anatomy of a patient in subsequent scans following a single baseline image. Such predictive modeling promises to facilitate novel analyses in both voxel-level studies and longitudinal biomarker evaluation. We capture anatomical change through a combination of population-wide regression and a non-parametric model of the subject's health based on individual genetic and clinical indicators. In contrast to classical correlation and longitudinal analysis, we focus on predicting new observations from a single subject observation. We demonstrate prediction of follow-up anatomical scans in the ADNI cohort, and illustrate a novel analysis approach that compares a patient's scans to the predicted subject-specific healthy anatomical trajectory. The code is available at https://github.com/adalca/voxelorb.

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Adrian V. Dalca, Ramesh Sridharan, Mert R. Sabuncu, Polina Golland. 2020-10-09. Predictive Modeling of Anatomy with Genetic and Clinical Data. https://arxiv.org/abs/2010.04757

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