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arXiv · 2012.04214

Noise-induced acceleration of single molecule kinesin-1

Takayuki Ariga·Keito Tateishi·Michio Tomishige·Daisuke Mizuno
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Abstract

The movement of single kinesin molecules was observed while applying noisy external forces that mimic intracellular active fluctuations. We found kinesin accelerates under noise, especially when a large hindering load is added. The behavior quantitatively conformed to a theoretical model that describes the kinesin movement with simple two-state reactions. The universality of the kinetic theory suggests that intracellular enzymes share a similar noise-induced acceleration mechanism, i.e. active fluctuations in cells are not just noise but are utilized to promote various physiological processes.

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Takayuki Ariga, Keito Tateishi, Michio Tomishige, Daisuke Mizuno. 2021-09-14. Noise-induced acceleration of single molecule kinesin-1. https://doi.org/10.1103/physrevlett.127.178101

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