arXiv subjects

Michio Tomishige

Publications and source records attributed to Michio Tomishige.

2 recordsLinked to original sources

arXiv2021

Noise-induced acceleration of single molecule kinesin-1

The movement of single kinesin molecules was observed while applying noisy external forces that mimic intracellular active fluctuations. We found kinesin accelerates under noise, especially when a large hindering load is added. The behavior quantitatively conformed to a theoretical model that describes the kinesin movement with simple two-state reactions. The universality of the kinetic theory suggests that intracellular enzymes share a similar noise-induced acceleration mechanism, i.e. active fluctuations in cells are not just noise but are utilized to promote various physiological processes.

physics.bio-ph↗

arXiv2018

Nonequilibrium Energetics of Molecular Motor Kinesin

Nonequilibrium energetics of single molecule translational motor kinesin was investigated by measuring heat dissipation from the violation of the fluctuation-response relation of a probe attached to the motor using optical tweezers. The sum of the dissipation and work did not amount to the input free energy change, indicating large hidden dissipation exists. Possible sources of the hidden dissipation were explored by analyzing the Langevin dynamics of the probe, which incorporates the two-state Markov stepper as a kinesin model. We conclude that internal dissipation is dominant.

physics.bio-ph↗