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arXiv · 2105.10215

Synchronization and enhanced catalysis of mechanically coupled enzymes

Jaime Agudo-Canalejo·Tunrayo Adeleke-Larodo·Pierre Illien·Ramin Golestanian
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Abstract

We examine the stochastic dynamics of two enzymes that are mechanically coupled to each other, e.g., through an elastic substrate or a fluid medium. The enzymes undergo conformational changes during their catalytic cycle, which itself is driven by stochastic steps along a biased chemical free energy landscape. We find conditions under which the enzymes can synchronize their catalytic steps, and discover that the coupling can lead to a significant enhancement in their overall catalytic rate. Both effects can be understood as arising from a global bifurcation in the underlying dynamical system at sufficiently strong coupling. Our findings suggest that, despite their molecular scale, enzymes can be cooperative and improve their performance in metabolic clusters.

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Jaime Agudo-Canalejo, Tunrayo Adeleke-Larodo, Pierre Illien, Ramin Golestanian. 2021-11-15. Synchronization and enhanced catalysis of mechanically coupled enzymes. https://doi.org/10.1103/physrevlett.127.208103

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