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arXiv · 2111.03121

Activity-induced instabilities of brain organoids

Kristian Thijssen·Guido L. A. Kusters·Amin Doostmohammadi
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Abstract

We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids.

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Kristian Thijssen, Guido L. A. Kusters, Amin Doostmohammadi. 2021-11-04. Activity-induced instabilities of brain organoids. https://arxiv.org/abs/2111.03121

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