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arXiv · 2207.03096

Single multimode fiber for in vivo light-field encoded nano-imaging

Zhong Wen·Zhenyu Dong·Chenlei Pang·Clemens F. Kaminski·Qilin Deng·Jinggang Xu·Liqiang Wang·Songguo Liu·Jianbin Tang·Wei Chen·Xu Liu·Qing Yang
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Abstract

Super-resolution microscopy normally requiring complex and cumbersome optics is not applicable for in situ imaging through a narrow channel. Here, we demonstrate single hair-thin multimode fiber (MMF) endoscope (less than 250 ${\mu}m$) for in vivo light-field nano-imaging, which is called spatial-frequency tracking adaptive beacon light-field encoded nano-endoscopy (STABLE nano-endoscopy) that enables three-dimensional (3D) subcellular-scale imaging. Spatial-frequency tracking provides up to $10^3$ Hz disorder tracking that ensures stable imaging in long-haul MMFs (up to 200 m) under various conditions. Full-vector modulation and fluorescence emission difference are combined to enhance the imaging signal-to-noise ratio two times and to improve the resolution to sub-diffraction-limited 250 nm (${\lambda}/3NA$). STABLE nano-endoscopy and white-light endoscopy (WLE) are integrated to achieve cross-scale in vivo imaging inside the lumen. This high-resolution and robust observation in a minimally invasive manner paves the way to gain a deeper understanding of the disease mechanisms and to bridge clinical and biological sciences.

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Zhong Wen, Zhenyu Dong, Chenlei Pang, Clemens F. Kaminski, Qilin Deng, Jinggang Xu, Liqiang Wang, Songguo Liu, Jianbin Tang, Wei Chen, Xu Liu, Qing Yang. 2022-07-07. Single multimode fiber for in vivo light-field encoded nano-imaging. https://doi.org/10.1038/s41566-023-01240-x

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