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arXiv · 2211.03517

Graphene-Induced Energy Transfer for Quantitative Membrane Biophysics at Sub-Nanometer Resolution

Tao Chen·Arindam Ghosh·Jörg Enderlein
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Abstract

Graphene-induced energy transfer (GIET) is a recently developed fluorescence-spectroscopic technique that achieves sub-nanometric optical localization of fluorophores along the optical axis of a microscope. GIET is based on the near-field energy transfer from an optically excited fluorescent molecule to a single sheet of graphene. It has been successfully used for estimating inter-leaflet distances of single lipid bilayers, and for investigating the membrane organization of living mitochondria. In this study, we use GIET to measure the cholesterol-induced subtle changes of membrane thickness at the nanoscale. We quantify membrane thickness variations in supported lipid bilayers (SLBs) as a function of lipid composition and increasing cholesterol content. Our findings demonstrate that GIET is an extremely sensitive tool for investigating nanometric structural changes in bio-membranes.

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Tao Chen, Arindam Ghosh, Jörg Enderlein. 2022-11-07. Graphene-Induced Energy Transfer for Quantitative Membrane Biophysics at Sub-Nanometer Resolution. https://arxiv.org/abs/2211.03517

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