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arXiv · 2303.01764

A chemotaxis reaction-diffusion model for Multiple Sclerosis with Allee effect

Marzia Bisi·Maria Groppi·Giorgio Martalò·Cinzia Soresina
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Abstract

In this paper, we study a modification of the mathematical model describing inflammation and demyelination patterns in the brain caused by Multiple Sclerosis proposed in [Lombardo et al. (2017), Journal of Mathematical Biology, 75, 373--417]. In particular, we hypothesize a minimal amount of macrophages to be able to start and sustain the inflammatory response. Thus, the model function for macrophage activation includes an Allee effect. We investigate the emergence of Turing patterns by combining linearised and weakly nonlinear analysis, bifurcation diagrams and numerical simulations, focusing on the comparison with the previous model.

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Marzia Bisi, Maria Groppi, Giorgio Martalò, Cinzia Soresina. 2023-03-03. A chemotaxis reaction-diffusion model for Multiple Sclerosis with Allee effect. https://arxiv.org/abs/2303.01764

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