Rate enhancement of gated drift-diffusion process by optimal resetting

Abstract

`Gating' is a widely observed phenomenon in biochemistry that describes the transition between the activated (or open) and deactivated (or closed) states of an ion-channel, which makes transport through that channel highly selective. In general, gating is a mechanism that imposes an additional restriction on a transport, as the process ends only when the `gate' is open and continues otherwise. When diffusion occurs in presence of a constant bias to a {\it gated} target, i.e., to a target that switches between an open and a closed state, the dynamics essentially slows down compared to {\it ungated} drift-diffusion, resulting in an increase in the mean completion time. In this work, we utilize stochastic resetting as an external protocol to counterbalance the delay due to gating. We consider a particle that undergoes drift-diffusion in the presence of a stochastically gated target and is moreover subjected to a rate-limiting resetting dynamics. Calculating the minimal mean completion time rendered by an optimal resetting for this exactly-solvable system, we construct a phase diagram that owns three distinct phases: (i) where resetting can make gated drift-diffusion faster even compared to the original ungated process, (ii) where resetting still expedites gated drift-diffusion, but not beyond the original ungated process, and (iii) where resetting fails to expedite gated drift-diffusion. Gated drift-diffusion aptly models various stochastic processes such as chemical reactions that exclusively take place for certain activated state of the reactants. Our work predicts the conditions where stochastic resetting can act as a useful strategy to enhance the rate of such processes without compromising on their selectivity.