SearcharxivSearch

arXiv · 2308.07162

Evolution of funding for collaborative health research towards higher-level patient-oriented research. A comparison of the European Union Framework Programmes to the program funding by the United States National Institutes of Health

Abstract

Public research funding agencies increasingly seek to steer health research toward higher levels of translation and societal relevance. Yet it remains unclear to what extent such policy shifts are effectively implemented and reflected in funded projects and scientific outputs. This study examines evolution and changes in the orientation of health research portfolios since 2008 within European funding (Framework Programmes FP7 and Horizon 2020 funding for collaborative health research, FP-HR, and ERC Life Sciences grants), in comparison to NIH funding for collaborative research (P01, U01, and UM1). Using large-scale text analysis and supervised classification, we analyze both project descriptions and the associated scientific publications. At the project level, the EU FP-HR show pronounced shifts toward population-level, diagnostic, and health systems-oriented research, whereas investigator-driven ERC life sciences, NIH P01 and U01, display greater stability with a predominance of basic biomedical research. Publication-level analyses reveal more moderate changes, with basic biomedical research remaining a central component including in EU FP-HR, indicating partial translation of funding priorities into outputs. By jointly analyzing projects and publications, this study identifies and distinguishes between changes in funder expectations and realized research trajectories, highlighting how strategic funding shapes research portfolios within enduring epistemic and institutional constraints.

Explore related subjects

Keep this discovery

BibTeXRIS

David Fajardo-Ortiz, Bart Thijs, Wolfgang Glanzel, Karin R. Sipido. 2023-08-14. Evolution of funding for collaborative health research towards higher-level patient-oriented research. A comparison of the European Union Framework Programmes to the program funding by the United States National Institutes of Health. https://doi.org/10.1162/qss.a.472

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

INDRA: A New AI Tool for Exploring Tobacco, Fossil Fuel, and Chemical Industry Archives

Five decades of litigation have disgorged hundreds of millions of pages of formerly secret business records from the tobacco industry, along with documents from the makers of drugs, chemicals, food, firearms, and fossil fuels. Yet these archives have been effectively inaccessible to general-purpose large language models (LLMs) because they have never been compiled into an LLM-readable corpus. Chatbots may be familiar with some of the materials contained in such archives but, with no direct access to the documents, they are vulnerable to hallucination and other defects. Here we introduce INDRA, a research platform designed to remedy such failures by embedding the conventions of archival historiography into a system-level protocol governing every output. The platform federates UCSF's Industry Documents Library, Columbia and CUNY's ToxicDocs, Stanford's SRITA, and other heretofore siloed collections, and provides three interlinked safeguards: (1) a closed evidentiary sandbox confines the model to a user-selected corpus, blocking retrieval from external sources that could introduce bias; (2) real-time provenance tagging marks the boundary between archival evidence and parametric inference; and (3) a system-level protocol enforced by deterministic scripts guides the structure of every output. Together these safeguards prevent the model from conflating "the documents say X" with "I think X" or "I learned X from prior training." The result is an LLM-powered research partner enabling massive multi-archival investigations, a tool whose outputs are designed to be checked rather than trusted, and whose architecture makes the conditions of knowledge production visible and auditable. Three case studies demonstrate the method's analytical value and limitations, including what we call the Heraclitus effect, the steppingstone dilemma, and the gullibility (or mafia) problem.

cs.DL

Wavering Oracles: Selective Updating and Correlated Failures in LLMs and Their Implications for Scientific Workflows

Scientific workflows increasingly use repeated queries, multiple models, and interacting agents. Reliability therefore depends on whether models preserve correct conclusions, accept valid corrections, and contribute errors that a selector can distinguish. Using SycoBench- 600 as a controlled measurement substrate, we evaluate these requirements through selective updating, defined by resistance to misleading suggestions and uptake of correct suggestions. The study covers ten models and 17,055 trajectories. Published models span 13.4 to 71.6 percentage points in selectivity. Under identical local evaluation, Qwen3-4B is selectively adaptive at 45.6 points, Gemma3-4B is destabilized at minus 14.1 points, and SmolLM3-3B follows both correct and wrong explicit suggestions, producing zero selectivity. Matched interventions identify model specific responses to doubt, authority, and explicit advice. Among seven published models, the best reaches 95.3 percent accuracy, plurality reaches 88.6 percent, and the oracle ceiling is 99.8 percent. Mean error correlation of 0.285 reduces seven models to an effective independent count of 2.58. A leave-one-stem-family-out reliability selector reaches 96.2 percent, recovering 67.7 percent of the plurality-to-oracle gap. These results establish selective updating, error diversity, and calibrated adjudication as jointly measurable design targets for multi-model scientific workflows.

cs.DL

Same Problem, Different Field: Cross-Domain Solution Import via Domain-Stripped Computational Fingerprints

The same underlying computational problem is solved across unrelated fields under different names: recursive Bayesian state estimation appears as a "Kalman filter" in control, "Bayesian forecasting" in pharmacokinetics, and "data assimilation" in geoscience. Topical and citation-based scientific embeddings cannot see this shared problem. We distill each paper once into a domain- and method-name-stripped faceted computational fingerprint, a free-text mechanism skeleton plus controlled computational facets. We define a tunable, facet-selectable distance over it. The goal is solution import: surface cross-field pairs solving the same problem, so a bespoke implementation can be swapped for another field's standard, specialized solver. On a benchmark of 18 method families across 109 papers, the skeleton lifts cross-domain retrieval average precision over the abstract from 0.222 to 0.513, and the whole fingerprint reaches 0.557. Strikingly, four trained scientific embedders all fall below plain abstract+TF-IDF: they encode topical and citation similarity, the wrong signal for this task. The gain is the representation: the abstract-to-skeleton swap lifts every embedder, and the pipeline is one cached LLM call per paper plus a cheap embedder. An interventional re-skin / math-edit test shows the fingerprint tracks the computation, not the field. On a 501-paper wild corpus, known twins dominate the top of the ranking (23 of the top 30); with planted pairs excluded from the results, three blind LLM judges rate 3 of the top 5 and 8 of the top 30 pairs genuine import candidates, and 0 of 30 random ones. The human verification is the four executed imports: in one, an open standard solver reproduces a bespoke clinical dosing engine's output. We release the benchmark, the code, and the distillation prompt.

cs.DL