Explainable Artificial Intelligence for Drug Discovery and Development -- A Comprehensive Survey

Roohallah Alizadehsani; Solomon Sunday Oyelere; Sadiq Hussain; Rene Ripardo Calixto; Victor Hugo C. de Albuquerque; Mohamad Roshanzamir; Mohamed Rahouti; Senthil Kumar Jagatheesaperumal

arXiv · 2309.12177

Explainable Artificial Intelligence for Drug Discovery and Development -- A Comprehensive Survey

Roohallah Alizadehsani·Solomon Sunday Oyelere·Sadiq Hussain·Rene Ripardo Calixto·Victor Hugo C. de Albuquerque·Mohamad Roshanzamir·Mohamed Rahouti·Senthil Kumar Jagatheesaperumal

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Abstract

The field of drug discovery has experienced a remarkable transformation with the advent of artificial intelligence (AI) and machine learning (ML) technologies. However, as these AI and ML models are becoming more complex, there is a growing need for transparency and interpretability of the models. Explainable Artificial Intelligence (XAI) is a novel approach that addresses this issue and provides a more interpretable understanding of the predictions made by machine learning models. In recent years, there has been an increasing interest in the application of XAI techniques to drug discovery. This review article provides a comprehensive overview of the current state-of-the-art in XAI for drug discovery, including various XAI methods, their application in drug discovery, and the challenges and limitations of XAI techniques in drug discovery. The article also covers the application of XAI in drug discovery, including target identification, compound design, and toxicity prediction. Furthermore, the article suggests potential future research directions for the application of XAI in drug discovery. The aim of this review article is to provide a comprehensive understanding of the current state of XAI in drug discovery and its potential to transform the field.

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Roohallah Alizadehsani, Solomon Sunday Oyelere, Sadiq Hussain, Rene Ripardo Calixto, Victor Hugo C. de Albuquerque, Mohamad Roshanzamir, Mohamed Rahouti, Senthil Kumar Jagatheesaperumal. 2023-09-21. Explainable Artificial Intelligence for Drug Discovery and Development -- A Comprehensive Survey. https://arxiv.org/abs/2309.12177

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