Quantifying white matter hyperintensity and brain volumes in heterogeneous clinical and low-field portable MRI

Pablo Laso; Stefano Cerri; Annabel Sorby-Adams; Jennifer Guo; Farrah Mateen; Philipp Goebl; Jiaming Wu; Peirong Liu; Hongwei Li; Sean I. Young; Benjamin Billot; Oula Puonti; Gordon Sze; Sam Payabavash; Adam DeHavenon; Kevin N. Sheth; Matthew S. Rosen; John Kirsch; Nicola Strisciuglio; Jelmer M. Wolterink; Arman Eshaghi; Frederik Barkhof; W. Taylor Kimberly; Juan Eugenio Iglesias

arXiv · 2312.05119

Quantifying white matter hyperintensity and brain volumes in heterogeneous clinical and low-field portable MRI

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Abstract

Brain atrophy and white matter hyperintensity (WMH) are critical neuroimaging features for ascertaining brain injury in cerebrovascular disease and multiple sclerosis. Automated segmentation and quantification is desirable but existing methods require high-resolution MRI with good signal-to-noise ratio (SNR). This precludes application to clinical and low-field portable MRI (pMRI) scans, thus hampering large-scale tracking of atrophy and WMH progression, especially in underserved areas where pMRI has huge potential. Here we present a method that segments white matter hyperintensity and 36 brain regions from scans of any resolution and contrast (including pMRI) without retraining. We show results on eight public datasets and on a private dataset with paired high- and low-field scans (3T and 64mT), where we attain strong correlation between the WMH ($\rho$=.85) and hippocampal volumes (r=.89) estimated at both fields. Our method is publicly available as part of FreeSurfer, at: http://surfer.nmr.mgh.harvard.edu/fswiki/WMH-SynthSeg.

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Pablo Laso, Stefano Cerri, Annabel Sorby-Adams, Jennifer Guo, Farrah Mateen, Philipp Goebl, Jiaming Wu, Peirong Liu, Hongwei Li, Sean I. Young, Benjamin Billot, Oula Puonti, Gordon Sze, Sam Payabavash, Adam DeHavenon, Kevin N. Sheth, Matthew S. Rosen, John Kirsch, Nicola Strisciuglio, Jelmer M. Wolterink, Arman Eshaghi, Frederik Barkhof, W. Taylor Kimberly, Juan Eugenio Iglesias. 2023-12-08. Quantifying white matter hyperintensity and brain volumes in heterogeneous clinical and low-field portable MRI. https://arxiv.org/abs/2312.05119

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