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arXiv · 2401.08701

In-silico Analysis of Hemodynamic Indicators in Idealized Stented Coronary Arteries for Varying Stent Indentation

Anna Ranno·Kiran Manjunatha·Anne Glitz·Nicole Schaaps·Stefanie Reese·Felix Vogt·Marek Behr
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Abstract

In this work, we investigate the effects of stent indentation on hemodynamic indicators in stented coronary arteries. Our aim is to assess in-silico risk factors for in-stent restenosis (ISR) and thrombosis after stent implantation. The proposed model is applied to an idealized artery with Xience V stent for four indentation percentages and three mesh refinements. We analyze the patterns of hemodynamic indicators arising from different stent indentations and propose an empirical frequency analysis of time-averaged WSS (TAWSS), oscillatory shear index (OSI), and relative residence time (RRT). We observe that higher indentations display higher frequency of critically low TAWSS and non-physiological OSI and RRT. Furthermore, an appropriate mesh refinement is needed for accurate representation of hemodynamics in the stent vicinity. The results provide physics-based evidence for the correlation between high indentation and ISR.

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Anna Ranno, Kiran Manjunatha, Anne Glitz, Nicole Schaaps, Stefanie Reese, Felix Vogt, Marek Behr. 2024-01-14. In-silico Analysis of Hemodynamic Indicators in Idealized Stented Coronary Arteries for Varying Stent Indentation. https://doi.org/10.1080/10255842.2024.2382819

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