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arXiv · 2403.14994

Enhancing Positronium Lifetime Imaging through Two-Component Reconstruction in Time-of-Flight Positron Emission Tomography

Zhuo Chen·Chien-Min Kao·Hsin-Hsiung Huang·Lingling An
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Abstract

Positron Emission Tomography (PET) is a crucial tool in medical imaging, particularly for diagnosing diseases like cancer and Alzheimer's. The advent of Positronium Lifetime Imaging (PLI) has opened new avenues for assessing the tissue micro-environment, which is vital for early-stage disease detection. In this study, we introduce a two-component reconstruction model for PLI in Time-of-Flight (TOF) PET, incorporating both ortho-positronium and para-positronium decays. Our model enhances the accuracy of positronium imaging by providing a more detailed representation of the tissue environment. We conducted simulation studies to evaluate the performance of our model and compared it with existing single-component models. The results demonstrate the superiority of the two-component model in capturing the intricacies of the tissue micro-environment, thus paving the way for more precise and informative PET diagnostics.

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Zhuo Chen, Chien-Min Kao, Hsin-Hsiung Huang, Lingling An. 2024-03-22. Enhancing Positronium Lifetime Imaging through Two-Component Reconstruction in Time-of-Flight Positron Emission Tomography. https://arxiv.org/abs/2403.14994

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