Exploring LLM Multi-Agents for ICD Coding

Abstract

To address the limitations of Large Language Models (LLMs) in the International Classification of Diseases (ICD) coding task, where they often produce inaccurate and incomplete prediction results due to the high-dimensional and skewed distribution of the ICD codes, and often lack interpretability and reliability as well. We introduce an innovative multi-agent approach for ICD coding which mimics the ICD coding assignment procedure in real-world settings, comprising five distinct agents: the patient, physician, coder, reviewer, and adjuster. Each agent utilizes an LLM-based model tailored to their specific role within the coding process. We also integrate the system with Electronic Health Record (HER)'s SOAP (subjective, objective, assessment and plan) structure to boost the performances. We compare our method with a system of agents designed solely by LLMs and other strong baselines and evaluate it using the Medical Information Mart for Intensive Care III (MIMIC-III) dataset. Our multi-agent coding framework significantly outperforms Zero-shot Chain of Thought (CoT) prompting and self-consistency with CoT (CoT-SC) in coding common and rare ICD codes. An ablation study validates the effectiveness of the designated agent roles. it also outperforms the LLM-designed agent system. Moreover, our method achieves comparable results to state-of-the-art ICD coding methods that require extensive pre-training or fine-tuning, and outperforms them in rare code accuracy, and explainability. Additionally, we demonstrate the method's practical applicability by presenting its performance in scenarios not limited by the common or rare ICD code constraints.The proposed multi-agent method for ICD coding effectively mimics the real-world coding process and improves performance on both common and rare codes.