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arXiv · 2408.13039

Superimposed Hi-C: A Solution Proposed for Identifying Single Cell's Chromosomal Interactions

Jia Zhang·Li Xiao·Peng Qi·Yaling Zeng·Xumeng Chen·Duan-fang Liao·Kai Li
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Abstract

Hi-C sequencing is widely used for analyzing chromosomal interactions. In this study, we propose "superimposed Hi-C" which features paired EcoP15I sites in a linker to facilitate sticky-end ligation with target DNAs. Superimposed Hi-C overcomes Hi-C's technical limitations, enabling the identification of single cell's chromosomal interactions.

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Jia Zhang, Li Xiao, Peng Qi, Yaling Zeng, Xumeng Chen, Duan-fang Liao, Kai Li. 2024-08-23. Superimposed Hi-C: A Solution Proposed for Identifying Single Cell's Chromosomal Interactions. https://arxiv.org/abs/2408.13039

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