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arXiv · 2409.18998

Controlled LLM-based Reasoning for Clinical Trial Retrieval

Mael Jullien·Alex Bogatu·Harriet Unsworth·Andre Freitas
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Abstract

Matching patients to clinical trials demands a systematic and reasoned interpretation of documents which require significant expert-level background knowledge, over a complex set of well-defined eligibility criteria. Moreover, this interpretation process needs to operate at scale, over vast knowledge bases of trials. In this paper, we propose a scalable method that extends the capabilities of LLMs in the direction of systematizing the reasoning over sets of medical eligibility criteria, evaluating it in the context of real-world cases. The proposed method overlays a Set-guided reasoning method for LLMs. The proposed framework is evaluated on TREC 2022 Clinical Trials, achieving results superior to the state-of-the-art: NDCG@10 of 0.693 and Precision@10 of 0.73.

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Mael Jullien, Alex Bogatu, Harriet Unsworth, Andre Freitas. 2024-09-19. Controlled LLM-based Reasoning for Clinical Trial Retrieval. https://arxiv.org/abs/2409.18998

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