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arXiv · 2410.04137

Adapter-dependent Adapter Methylation Assay

Jia Zhang·Peng Qi·Li Xiao·Mengxi Yuan·Jun Chuan·Yaling Zeng·Li-mei Lin·Yue Gu·Yan Zhang·Duan-fang Liao·Kai Li
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Abstract

Sensitive and reliable methylation assay is important for oncogentic studies and clinical applications. Here, a new methylation assay was developed by the use of adapter-dependent adapter in library preparation. This new assay avoids the use of bisulfite and provides a simple and highly sensitive scanning of methylation spectra of circulating free DNA and genomic DNA.

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Jia Zhang, Peng Qi, Li Xiao, Mengxi Yuan, Jun Chuan, Yaling Zeng, Li-mei Lin, Yue Gu, Yan Zhang, Duan-fang Liao, Kai Li. 2024-10-05. Adapter-dependent Adapter Methylation Assay. https://arxiv.org/abs/2410.04137

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