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arXiv · 2501.11875

Developing an Agent-Based Mathematical Model for Simulating Post-Irradiation Cellular Response: A Crucial Component of a Digital Twin Framework for Personalized Radiation Treatment

Ruirui Liu·Marciek H. Swat·James A. Glazier·Yu Lei·Sumin Zhou·Kathryn A. Higley
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Abstract

In this study, we present the Physical-Bio Translator, an agent-based simulation model designed to simulate cellular responses following irradiation. This simulation framework is based on a novel cell-state transition model that accurately reflects the characteristics of irradiated cells. To validate the Physical-Bio Translator, we performed simulations of cell phase evolution, cell phenotype evolution, and cell survival. The results indicate that the Physical-Bio Translator effectively replicates experimental cell irradiation outcomes, suggesting that digital cell irradiation experiments can be conducted via computer simulation, offering a more sophisticated model for radiation biology. This work lays the foundation for developing a robust and versatile digital twin at multicellular or tissue scales, aiming to comprehensively study and predict patient responses to radiation therapy.

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Ruirui Liu, Marciek H. Swat, James A. Glazier, Yu Lei, Sumin Zhou, Kathryn A. Higley. 2025-01-21. Developing an Agent-Based Mathematical Model for Simulating Post-Irradiation Cellular Response: A Crucial Component of a Digital Twin Framework for Personalized Radiation Treatment. https://arxiv.org/abs/2501.11875

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