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arXiv · 2504.09616

Failure and Success in Single-Drug Control of Antimicrobial Resistance

Alejandro Anderson·Rami Katz·Francesca Calà Campana·Giulia Giordano
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Abstract

We propose a mathematical model of Antimicrobial Resistance in the host to predict the failure of two antagonists of bacterial growth: the immune response and a single-antibiotic therapy. After characterising the initial bacterial load that cannot be cleared by the immune system alone, we define the success set of initial conditions for which an infection-free equilibrium can be reached by a viable single-antibiotic therapy, and we provide a rigorously defined inner approximation of the set. For initial conditions within the success set, we propose an optimal control framework to design single-drug therapies.

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Alejandro Anderson, Rami Katz, Francesca Calà Campana, Giulia Giordano. 2025-04-13. Failure and Success in Single-Drug Control of Antimicrobial Resistance. https://doi.org/10.1109/lcsys.2025.3576308

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