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arXiv · 2505.17715

Biomechanical Mapping of Tumor Growth: A Novel Method to Quantify Glioma Infiltration and Mass Effect

Carles López-Mateu·Maria Gómez-Mahiques·F. Javier Gil-Terrón·Víctor Montosa-i-Micó·Donatas Sederevičius·Kyrre E. Emblem·Juan M. García-Gómez·Elies Fuster-García
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Abstract

Glioblastoma (GBM) exhibits two principal growth phenotypes: infiltrative, characterized by diffuse invasion with minimal mass effect, and proliferative, characterized by pronounced tissue compression. Their quantitative delineation and prognostic implications remain uncertain. We introduce an MRI-derived biomarker, the dynamic infiltration rate (DIR), defined as the ratio of tumor-volume expansion to mass-effect--induced peritumoral compression, and evaluate it in silico and clinically. In a synthetic dataset spanning realistic infiltrative-proliferative spectra, DIR correlates strongly with ground truth ($R^{2}=0.85$). Applied to patient data, a data-driven threshold separates high- and low-infiltration groups with markedly different overall survival (median 16.0 versus 35.2 weeks; log-rank $p<0.001$; hazard ratio 2.49). Multivariate Cox analysis adjusted for age, sex, and MGMT status confirms DIR as an independent prognostic factor (HR = 1.38, 95% CI 1.12-1.70; $p=0.0027$). DIR therefore differentiates proliferative from infiltrative GBM phenotypes and provides prognostic information that could inform personalized therapy and follow-up.

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Carles López-Mateu, Maria Gómez-Mahiques, F. Javier Gil-Terrón, Víctor Montosa-i-Micó, Donatas Sederevičius, Kyrre E. Emblem, Juan M. García-Gómez, Elies Fuster-García. 2025-05-23. Biomechanical Mapping of Tumor Growth: A Novel Method to Quantify Glioma Infiltration and Mass Effect. https://arxiv.org/abs/2505.17715

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