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arXiv · 2506.03017

Adjusting Tissue Puncture Omnidirectionally In Situ with Pneumatic Rotatable Biopsy Mechanism and Hierarchical Airflow Management in Tortuous Luminal Pathways

Botao Lin·Tinghua Zhang·Sishen Yuan·Tiantian Wang·Jiaole Wang·Wu Yuan·Hongliang Ren
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Abstract

In situ tissue biopsy with an endoluminal catheter is an efficient approach for disease diagnosis, featuring low invasiveness and few complications. However, the endoluminal catheter struggles to adjust the biopsy direction by distal endoscope bending or proximal twisting for tissue sampling within the tortuous luminal organs, due to friction-induced hysteresis and narrow spaces. Here, we propose a pneumatically-driven robotic catheter enabling the adjustment of the sampling direction without twisting the catheter for an accurate in situ omnidirectional biopsy. The distal end of the robotic catheter consists of a pneumatic bending actuator for the catheter's deployment in torturous luminal organs and a pneumatic rotatable biopsy mechanism (PRBM). By hierarchical airflow control, the PRBM can adjust the biopsy direction under low airflow and deploy the biopsy needle with higher airflow, allowing for rapid omnidirectional sampling of tissue in situ. This paper describes the design, modeling, and characterization of the proposed robotic catheter, including repeated deployment assessments of the biopsy needle, puncture force measurement, and validation via phantom tests. The PRBM prototype has six sampling directions evenly distributed across 360 degrees when actuated by a positive pressure of 0.3 MPa. The pneumatically-driven robotic catheter provides a novel biopsy strategy, potentially facilitating in situ multidirectional biopsies in tortuous luminal organs with minimum invasiveness.

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Botao Lin, Tinghua Zhang, Sishen Yuan, Tiantian Wang, Jiaole Wang, Wu Yuan, Hongliang Ren. 2025-06-03. Adjusting Tissue Puncture Omnidirectionally In Situ with Pneumatic Rotatable Biopsy Mechanism and Hierarchical Airflow Management in Tortuous Luminal Pathways. https://arxiv.org/abs/2506.03017

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