Self-propulsion via non-transitive phase coexistence in chemically active mixtures

Yicheng Qiang; Chengjie Luo; David Zwicker

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arXiv · 2508.09816

Self-propulsion via non-transitive phase coexistence in chemically active mixtures

Yicheng Qiang·Chengjie Luo·David Zwicker

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Abstract

Phase separation drives the formation of biomolecular condensates in cells, which comprise many components and sometimes possess multiple phases. The equilibrium physics of phase separation is well understood, but many components in condensates undergo active reactions. We demonstrate that such reactions affect phase separation by altering the chemical potential balance and by introducing an osmotic pressure difference at interfaces. However, the system does not permit a pseudo-pressure balance, and bulk compositions depend on which phases are in contact. Moreover, phase coexistence is no longer transitive, which enables self-propelled phases and more complex dynamics.

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Yicheng Qiang, Chengjie Luo, David Zwicker. 2025-08-13. Self-propulsion via non-transitive phase coexistence in chemically active mixtures. https://arxiv.org/abs/2508.09816

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