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arXiv · 2509.17869

Single image sensorless adaptive optics using phase-diversified multifocal array

Biwei Zhang·Qi Hu·Jingyu Wang·Martin J. Booth
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Abstract

Image-based sensorless adaptive optics is commonly used to improve microscope image quality through aberration compensation. However, its sequential nature leads to repeated sample exposures and a prolonged aberration estimation and correction process. In this work, we used a phase-diversified foci array to enhance the aberration-related information in multi-photon fluorescence microscope images. We showed that, through use of a neural network-based image processing algorithm, we can extract aberration from a single image frame. We discussed how the number of foci can affect the wavefront correction on a bead sample, and we showed that six foci, in general, perform better than two-foci or ten-foci arrangements. We also applied our technique to correct aberrations in biological samples, including a fixed brain tissue and BPAE cells slide.

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Biwei Zhang, Qi Hu, Jingyu Wang, Martin J. Booth. 2025-09-22. Single image sensorless adaptive optics using phase-diversified multifocal array. https://arxiv.org/abs/2509.17869

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