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arXiv · 2510.09982

Tumor Obliteration by Resonant Amplification (TOR) A Nonthermal, Spectrally-Targeted Approach to Cancer Disintegration

Cesar Mello·Fernando Medina da Cunha
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Abstract

Tumor Obliteration by Resonant Amplification (TOR) was evaluated purely in simulation. Forward models in COMSOL, ANSYS, and ABAQUS used the same small-strain rheology, nonthermal/noncavitational limits, and an emulated closed loop (phase-locked actuation plus contrast/safety gating). Over >= 200 Monte Carlo runs per setup, TOR produced per-focus extinction in 2.6-3.2 s at approx. 0.85-0.90 J/cm^3, with selectivity Q = 39 +/- 5, peak temperature rise dT_max <= 0.2 deg C, and CEM43 << 1, consistent with strictly nonthermal operation. Primary indices indicated high spectral fidelity and intrinsic safety margin: MMI = 0.92 +/- 0.03, SSR = 14.6 +/- 3.1 (circumscribed) / 11.2 +/- 2.4 (infiltrative), and ATI <= 0.8 of the matrix-failure threshold. Simulated foci matched FE predictions within +/- 150 um. A unitless reality-adherence score comparing four observables to consolidated literature ranges yielded A = 95% +/- 2% (BCa 95%). Organ-specific estimates were 95.1% (pancreatic ductal adenocarcinoma), 96.0% (prostatic acinar adenocarcinoma), and 94.2% (invasive ductal carcinoma of the breast). The delivery stack - tungsten micro-needle (300-500 um) with 5-25 um tip excursions, phase lock, and amplitude gating - operated in a small-strain, noncavitational regime, keeping off-target strain below safety limits by design. Mechanistically, mode-selective collapse implies suppression of core vesicle biogenesis and nociceptor drive; rim scanning is constrained by healthy-referenced bounds, motivating compact neuroimmune readouts in future tests. Overall, the calibrated multiphysics results support a reproducible, spectrum-locked path from modeling to benchtop: deterministic extinction at low energy, high selectivity, and strict thermal neutrality, with pre-registered experiments planned to confirm the predicted safety and efficacy envelopes.

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Cesar Mello, Fernando Medina da Cunha. 2025-10-11. Tumor Obliteration by Resonant Amplification (TOR) A Nonthermal, Spectrally-Targeted Approach to Cancer Disintegration. https://arxiv.org/abs/2510.09982

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