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arXiv · 2510.23140

Fast Voxel-Wise Kinetic Modeling in Dynamic PET using a Physics-Informed CycleGAN

Christian Salomonsen·Samuel Kuttner·Michael Kampffmeyer·Robert Jenssen·Kristoffer Wickstrøm·Jong Chul Ye·Elisabeth Wetzer
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Abstract

Tracer kinetic modeling serves a vital role in diagnosis, treatment planning, tracer development and oncology, but burdens practitioners with complex and invasive arterial input function estimation (AIF). We adopt a physics-informed CycleGAN showing promise in DCE-MRI quantification to dynamic PET quantification. Our experiments demonstrate sound AIF predictions and parameter maps closely resembling the reference.

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Christian Salomonsen, Samuel Kuttner, Michael Kampffmeyer, Robert Jenssen, Kristoffer Wickstrøm, Jong Chul Ye, Elisabeth Wetzer. 2025-10-27. Fast Voxel-Wise Kinetic Modeling in Dynamic PET using a Physics-Informed CycleGAN. https://arxiv.org/abs/2510.23140

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