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arXiv · 2511.16456

Entropy Transfer Throughout the Structure of PDZ-2 and TIM-Barrel Proteins. A Dynamic Gaussian Network Model Study

German Mino Galaz·Javier Patino Baez·Nicolas Mino Berdu·Jose Gonzalez Suarez
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Abstract

This research reports the entropy transfer throughout the tridimensional structure of PDZ-2 and TIM barrel structures using the dynamic Gaussian Network Model. The model predicts the allocation of the allosteric pathways of the PDZ-2. Moreover. A visualization analysis reveals that entropy and information is transported towards the effector site in PDZ-2 and near to the catalytic site of the TIM-Barrel protein. The results suggest the presence of a functional hierarchy that determine information and entropy flow directionality.

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German Mino Galaz, Javier Patino Baez, Nicolas Mino Berdu, Jose Gonzalez Suarez. 2025-11-20. Entropy Transfer Throughout the Structure of PDZ-2 and TIM-Barrel Proteins. A Dynamic Gaussian Network Model Study. https://arxiv.org/abs/2511.16456

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