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arXiv · 2512.10377

KRAS G12D protein screening for pancreatic cancer clinical trials using an AlGaN/GaN high electron mobility transistor biosensor

Sheng-Ting Hung·Cheng Yan Lee·Chen-Yu Lien·Cheng-Hsuan Chan·Ya-Han Yang·Quark Yungsung Chen·Kuang-Hung Cheng·Kung-Kai Kuo·Li-Wei Tu·Ching-Wen Chang
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Abstract

Clinical trials screening KRAS G12D protein for 30 pancreatic ductal adenocarcinoma (PDAC) patients and 30 healthy donors were conducted utilizing an AlGaN/GaN high electron mobility transistor (HEMT) biosensor. All resistance change ratios of PDAC patients are higher than the standard deviation above the mean resistance change ratio obtained from all healthy donors. The results demonstrate the effectiveness of the HEMT biosensor and reveal its potential for early detection of pancreatic cancer with KRAS G12D protein screening.

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Sheng-Ting Hung, Cheng Yan Lee, Chen-Yu Lien, Cheng-Hsuan Chan, Ya-Han Yang, Quark Yungsung Chen, Kuang-Hung Cheng, Kung-Kai Kuo, Li-Wei Tu, Ching-Wen Chang. 2025-12-11. KRAS G12D protein screening for pancreatic cancer clinical trials using an AlGaN/GaN high electron mobility transistor biosensor. https://doi.org/10.1109/jsen.2026.3669133

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