Beyond Point Estimates: Toward Proper Statistical Inferencing and Reporting of Intraclass Correlation Coefficients

Yufeng Liu; Xiangfei Hong; Shanbao Tong

Home/Archive/arXiv

arXiv · 2601.02765

Beyond Point Estimates: Toward Proper Statistical Inferencing and Reporting of Intraclass Correlation Coefficients

Yufeng Liu·Xiangfei Hong·Shanbao Tong

View original source ↗Read source document ↗Export metadata ↓

Abstract

Reporting test-retest reliability using the intraclass correlation coefficient (ICC) has received increasing attention due to the criticisms of poor transparency and replicability in neuroimaging research, as well as many other biomedical studies. Numerous studies have thus evaluated the reliability of their findings by comparing ICCs, however, they often failed to test statistical differences between ICCs or report confidence intervals. Relying solely on point estimates may preclude valid inference about population-level differences and compromise the reliability of conclusions. To address this issue, this study systematically reviewed the use of ICC in articles published in NeuroImage from 2022 to 2024, highlighting the prevalence of misreporting and misuse of ICCs. We further provide practical guidelines for conducting appropriate statistical inference on ICCs. For practitioners in this area, we introduce an online application for statistical testing and sample size estimation when utilizing ICCs. We recalculated confidence intervals and formally tested ICC values reported in the reviewed articles, thereby reassessing the original inferences. Our results demonstrate that exclusive reliance on point estimates could lead to unreliable or even misleading conclusions. Specifically, only two of the eleven reviewed articles provided unequivocally valid statistical inferences based on ICCs, whereas two articles failed to yield any valid inference at all, raising serious concerns about the replicability of findings in this field. These results underscore the urgent need for rigorous inferential frameworks when reporting and interpreting ICCs.

Explore related subjects

stat.ME stat.AP

Keep this discovery

BibTeX RIS

Yufeng Liu, Xiangfei Hong, Shanbao Tong. 2026-01-06. Beyond Point Estimates: Toward Proper Statistical Inferencing and Reporting of Intraclass Correlation Coefficients. https://arxiv.org/abs/2601.02765

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Surprise Reduction and Nullification in Bayesian and Inverse Bayesian Inference under Ambiguous Prediction-Error Attribution

In non-stationary environments, prediction errors may signal environmental change or transient outliers, and adaptive systems must track such changes without overreacting to outliers. We distinguish surprise reduction, which updates beliefs to fit observations, from surprise nullification, which weakens constraints imposed by the predictive structure, and formalize both within Bayesian and inverse Bayesian (BIB) inference. Belief and likelihood updates are derived from variational objectives sharing a nullification strength, determined endogenously by minimizing surprise under the candidate post-update predictive distribution. In the Gaussian case, nullification expands belief and likelihood variances by a common factor relative to standard Bayesian updating, leaving the ratio unchanged. BIB thus defers attribution of the prediction error, committing to neither latent-state change nor observation-process uncertainty. The nullification strength is carried over as a candidate and is maintained or released according to the predictive surprise of the next observation. In a mean estimation task with outliers and changepoints, no scanned parameter setting of a Sage-Husa-type adaptive Kalman filter, fixed-strength BIB variant, or belief-forgetting-only variant outperforms BIB in both changepoint tracking and post-outlier stability. An oracle-informed reduced Bayesian model tracks changepoints better but is less stable after outliers. Although BIB maintains no explicit hypotheses about changepoints or outliers, it generates event-dependent dynamics. The learning rate increases after changepoints, whereas after outliers, nullification is released, and this increase is suppressed. Deferring attribution and letting subsequent observations differentiate the responses may constitute a principle of adaptive inference in non-stationary environments.

stat.ME↗

arXiv2026

Generalized Ridge Refitting for the Lasso and Prediction Improvement Bounds

We study a class of Lasso based estimators obtained by applying a quadratic correction on the Lasso equicorrelation set. The penalty matrix determines both the magnitude and geometry of the correction and contains, among other cases, the isotropic Lasso--Ridge correction, least squares refitting, Gram proportional interpolation between the Lasso and least squares, and coordinate specific penalties. We first derive a closed form representation and isolate the positive gain component of the resulting prediction improvement. We then control the remaining stochastic linear term in expectation by localizing the random signed equicorrelation model around a deterministic reference support. This yields a finite sample expectation bound that explicitly accounts for the randomness induced by Lasso model selection. The resulting decomposition provides a unified framework for understanding when Lasso based quadratic corrections can improve prediction.

stat.ME↗

arXiv2026

Discretization in covariate-adaptive randomization: gains and losses

Covariate-adaptive randomization(CAR) is widely implemented in clinical trials to balance prognostic covariates across treatment arms. Continuous covariates are often discretized into strata in practice, yet their consequences are not clearly understood. This paper provides a comprehensive study of the impact of discretization on both the CAR design process and the inferential results thereafter. We establish the asymptotic properties of both imbalance measures and treatment effect estimators under discretized and non-discretized settings. Practical recommendations are given on when and how discretization should be employed. We show that discretization in design is generally recommended, as it enhances robustness against model misspecification. However, if the true model is known, the most efficient strategy is to balance covariates according to that model in the design. The theoretical results are corroborated by extensive simulation studies and an empirical application to a diabetes trial dataset. Together, the results clarify the gains and losses of discretization in CAR and pave the way for learning impact of discretization to other designs and beyond.

stat.ME↗