Preoperative Decline and Postoperative Recovery of Wearable-Derived Physical Activity Over a Four-Year Perioperative Period in Total Knee and Hip Arthroplasty: Evidence from the All of Us Research Program

Yuezhou Zhang; Amos Folarin; Callum Stewart; Hyunju Kim; Rongrong Zhong; Shaoxiong Sun; Richard JB Dobson

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arXiv · 2603.05741

Preoperative Decline and Postoperative Recovery of Wearable-Derived Physical Activity Over a Four-Year Perioperative Period in Total Knee and Hip Arthroplasty: Evidence from the All of Us Research Program

Yuezhou Zhang·Amos Folarin·Callum Stewart·Hyunju Kim·Rongrong Zhong·Shaoxiong Sun·Richard JB Dobson

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Abstract

Total knee arthroplasty (TKA) and total hip arthroplasty (THA) improve symptoms in end-stage osteoarthritis, yet long-term objective characterization of perioperative physical activity trajectories remains limited. We conducted a longitudinal observational study within the All of Us Research Program dataset, linking electronic health records with continuous Fitbit-derived step count data over a four-year perioperative window (two years before and two years after arthroplasty). Piecewise linear mixed-effects models characterized preoperative declines and postoperative recovery trajectories, and time-to-recovery was evaluated using Kaplan-Meier curves and Cox proportional hazards models under remote and immediate preoperative physical activity baseline definitions. Among 238 participants (147 TKA; 91 THA), both procedures exhibited progressive preoperative decline with distinct procedure-specific patterns and staged postoperative recovery: rapid improvement during weeks 1-6, decelerating gains through weeks 7-19/20, and subsequent stabilization through week 104. Recovery to remote and immediate baselines differed in timing (median 22 vs 13 weeks) and associated predictors. Higher immediate preoperative activity was associated with greater likelihood of recovery to habitual activity levels, underscoring the relevance of preoperative functional reserve and surgical timing. These findings demonstrate the potential of long-term wearable monitoring to refine assessment of functional outcomes, guide recovery expectations, and support perioperative management.

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Yuezhou Zhang, Amos Folarin, Callum Stewart, Hyunju Kim, Rongrong Zhong, Shaoxiong Sun, Richard JB Dobson. 2026-03-05. Preoperative Decline and Postoperative Recovery of Wearable-Derived Physical Activity Over a Four-Year Perioperative Period in Total Knee and Hip Arthroplasty: Evidence from the All of Us Research Program. https://arxiv.org/abs/2603.05741

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