Advancing Trustworthy AI in Healthcare Through Meta-Research: Results of an Interdisciplinary Design-Thinking Workshop

Valerie Bürger; Marlie Besouw; Jana Fehr; Riana Minocher; Emma Moorhead; Isabel Velarde; Louis Agha-Mir-Salim; Julia Amann; Alexandra Bannach-Brown; David B. Blumenthal; Kaitlyn Hair; Bert Heinrichs; Moritz Herrmann; Elizabeth Hofvenschiöld; Sune Holm; Anne A. H. de Hond; Sara Kijewski; Stuart McLennan; Timo Minssen; Marco S. Nobile; Nico Pfeifer; Jessica L. Rohmann; Tony Ross-Hellauer; Marija Slavkovik; Karin Tafur; Eleonora Viganò; Magnus Westerlund; Tracey Weissgerber; Vince I. Madai

arXiv · 2603.13286

Advancing Trustworthy AI in Healthcare Through Meta-Research: Results of an Interdisciplinary Design-Thinking Workshop

View original source ↗Read source document ↗Export metadata ↓

Abstract

Meta-research and Trustworthy AI (TAI) share common goals, namely improving evidence, robustness, and transparency, yet there is very little interplay between the two fields. To investigate the potential benefits of closer collaboration between the domains of TAI in healthcare and meta-research, we convened an interdisciplinary workshop funded by the Volkswagen Foundation in February 2025. The workshop aimed to collaboratively examine key challenges in translating AI ethics principles into practice and to identify potential solutions informed by meta-research approaches. A Design Thinking-informed co-creation approach was followed by an inductive descriptive analysis of the outputs. Our results demonstrate how meta-research can offer concrete contributions to address pressing challenges of TAI in healthcare. These challenges include the dynamic and complex nature of TAI ethical requirements and principles, common terminology and understanding of TAI, ensuring robustness, replicability, and reproducibility, choosing adequate evaluation metrics, lack of transparency, advancing preclinical biomedical research, and validation in real-world clinical environments. We present a catalog of ideas and a roadmap for future research, which synthesize existing interconnections and identify concrete next steps and open research gaps, thereby serving as a foundation for future interdisciplinary efforts.

Explore related subjects

cs.CY cs.AI

Keep this discovery

BibTeX RIS

Valerie Bürger, Marlie Besouw, Jana Fehr, Riana Minocher, Emma Moorhead, Isabel Velarde, Louis Agha-Mir-Salim, Julia Amann, Alexandra Bannach-Brown, David B. Blumenthal, Kaitlyn Hair, Bert Heinrichs, Moritz Herrmann, Elizabeth Hofvenschiöld, Sune Holm, Anne A. H. de Hond, Sara Kijewski, Stuart McLennan, Timo Minssen, Marco S. Nobile, Nico Pfeifer, Jessica L. Rohmann, Tony Ross-Hellauer, Marija Slavkovik, Karin Tafur, Eleonora Viganò, Magnus Westerlund, Tracey Weissgerber, Vince I. Madai. 2026-02-27. Advancing Trustworthy AI in Healthcare Through Meta-Research: Results of an Interdisciplinary Design-Thinking Workshop. https://arxiv.org/abs/2603.13286

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Work, Wellbeing, and Choice: Empirical Lessons for AI Futures

Advances in AI-driven automation have raised questions about how humans might find wellbeing in a world where paid employment is less necessary or less available than before. Paid work has been variously characterized as both a contributor and an impediment to human wellbeing. What is already known about the relationship between paid work and wellbeing? What factors influence wellbeing among people who do not work---or who do not need to work? And how might these factors bear upon prospective AI-induced economic transformations? To help provide empirical grounding for these questions, we survey the psychological, sociological, and economic literature that investigates the relationship between wellbeing and work. We draw on evidence from multiple populations, including the unemployed, retirees, lottery winners, and financially dependent spouses. This comparative review draws from studies across OECD countries, China, India, and Gulf states. We identify three key factors that mediate the relationship between work status and wellbeing: (1) agency and choice---whether the exit from work is voluntary or involuntary, as well as long-term agency; (2) the availability of alternative sources of work's latent benefits---such as volunteering, hobbies, or state-provisioned employment; and (3) social and systemic context---including cultural norms around work and the robustness of social safety nets. We draw on these three factors to derive specific implications for different AI automation scenarios, connecting the empirical evidence to concrete policy considerations.

cs.CY↗

arXiv2026

From Digital Accountability to Accountable Digitality Through Needs-Aware Information Systems: The Case of Auditable Child-Welfare Judgments

Digital accountability research asks how digital systems can, among other aims, be made transparent, explainable, auditable, contestable, and supportive of ongoing learning and improvement. This paper reverses the question: how can digital transformation make established human institutions more accountable? It theorizes this reversal as accountable digitality and specifies needs-aware information systems as the mediating mechanism. The hard and paradigmatic case is child-welfare judgment, where best-interest procedures must protect children, preserve confidentiality, and respect judicial independence while enabling aggregate learning about needs, reasons, exceptions, and disparities. The case is used diagnostically and illustratively to derive and examine the design logic, not as empirical evidence or validation. Conceptual design-oriented analysis decomposes and recombines digital and legal accountability under child-rights constraints, deriving a canonical theory-to-design chain, contingent mechanisms, implications, and safeguards. It advances IS responsibility and ethics research by showing how privacy-preserving, co-created, needs-aware information systems can support institutional self-knowledge and auditable justice.

cs.CY↗

arXiv2026

(Whose defaults?) Is artificial intelligence reorienting archaeological methods?

Generative AI and the practice of "vibe coding" are changing how archaeologists carry out computational research, but their effects on the discipline's range of methods is still understudied. In this paper, we evaluate whether large language models (LLMs) are narrowing the variety of methods archaeologists use. We first analysed approximately 119,000 archaeology abstracts from Scopus, covering publications from 2010 to 2025. Using a locally run LLM, we identified the computational methods reported in each abstract and organised them into 25 broad categories (L2) and 241 finer clusters (L3). A Bayesian Dirichlet-multinomial model of method composition within sub-disciplines found a small but credible shift in method use after 2023. However, this shift was smaller than the variation already present across the full study period. No individual technique showed a significant change, and overall methodological diversity increased rather than declined. We then ran a controlled experiment to see whether LLMs recommend a narrower set of methods than archaeologists have used in practice. Two different open-weight models were asked to suggest methods for 28 archaeological research problems, with prompts providing three levels of methodological guidance: novice, intermediate, and expert. Recommendation diversity was much lower than in the published literature, particularly without methodological guidance. The models also tended to favour methods that were widely used before 2023, and their recommendations more closely resembled the post-2023 literature. Taken together, these results are consistent with LLMs pushing methodological choice towards convergence, although our study cannot establish a causal effect. They raise a broader question: how can archaeology retain methodological diversity as LLMs become more involved in research?

cs.CY↗