arXiv subjects

Louis Agha-Mir-Salim

Publications and source records attributed to Louis Agha-Mir-Salim.

3 recordsLinked to original sources

arXiv2026

An Event-Driven Cloud-Native Wearable Analytics Framework for Real-Time Clinical Workloads

Continuous physiological monitoring using consumer-grade wearables offers a transformative opportunity for clinical care and research, yet integration remains hindered by device heterogeneity, proprietary data formats, and strict regulatory requirements. We present an event-driven, cloud-native system designed to ingest, normalize, and analyze high-frequency vital signs from wearables at scale and without vendor lock-in. The system design proposes a multi-layered microservice architecture using cluster orchestration. Data acquisition is handled via a cross-platform mobile application that leverages native health frameworks, ensuring compatibility across fragmented device ecosystems. To address interoperability, we implement an event-driven transformation pipeline using stream processing engines and specialized services to map raw measurements to the FHIR standard for medical interoperability. Our novel dependency-aware FHIR minimization scheme reduces storage overhead while maintaining lossless resource reconstruction. Furthermore, the platform integrates a modular data analytics and machine learning layer based on a medallion lakehouse architecture, supporting the full machine learning lifecycle from real-time stream processing to model serving. Performance evaluation demonstrates that the ingestion pipeline sustains 50 full ingestion requests per second with median response times under 8 ms, satisfying the low-latency requirements for real-time patient monitoring. Our open-source implementation adheres to regulatory compliance standards through role-based access control and secure service-to-service communication, providing a robust foundation for deploying wearable-based monitoring in institutional healthcare settings for clinical decision support and research workloads.

cs.DC↗

arXiv2026

Advancing Trustworthy AI in Healthcare Through Meta-Research: Results of an Interdisciplinary Design-Thinking Workshop

Meta-research and Trustworthy AI (TAI) share common goals, namely improving evidence, robustness, and transparency, yet there is very little interplay between the two fields. To investigate the potential benefits of closer collaboration between the domains of TAI in healthcare and meta-research, we convened an interdisciplinary workshop funded by the Volkswagen Foundation in February 2025. The workshop aimed to collaboratively examine key challenges in translating AI ethics principles into practice and to identify potential solutions informed by meta-research approaches. A Design Thinking-informed co-creation approach was followed by an inductive descriptive analysis of the outputs. Our results demonstrate how meta-research can offer concrete contributions to address pressing challenges of TAI in healthcare. These challenges include the dynamic and complex nature of TAI ethical requirements and principles, common terminology and understanding of TAI, ensuring robustness, replicability, and reproducibility, choosing adequate evaluation metrics, lack of transparency, advancing preclinical biomedical research, and validation in real-world clinical environments. We present a catalog of ideas and a roadmap for future research, which synthesize existing interconnections and identify concrete next steps and open research gaps, thereby serving as a foundation for future interdisciplinary efforts.

cs.CY↗

arXiv2021

Prediction of Blood Lactate Values in Critically Ill Patients: A Retrospective Multi-center Cohort Study

Purpose. Elevations in initially obtained serum lactate levels are strong predictors of mortality in critically ill patients. Identifying patients whose serum lactate levels are more likely to increase can alert physicians to intensify care and guide them in the frequency of tending the blood test. We investigate whether machine learning models can predict subsequent serum lactate changes. Methods. We investigated serum lactate change prediction using the MIMIC-III and eICU-CRD datasets in internal as well as external validation of the eICU cohort on the MIMIC-III cohort. Three subgroups were defined based on the initial lactate levels: i) normal group (<2 mmol/L), ii) mild group (2-4 mmol/L), and iii) severe group (>4 mmol/L). Outcomes were defined based on increase or decrease of serum lactate levels between the groups. We also performed sensitivity analysis by defining the outcome as lactate change of >10% and furthermore investigated the influence of the time interval between subsequent lactate measurements on predictive performance. Results. The LSTM models were able to predict deterioration of serum lactate values of MIMIC-III patients with an AUC of 0.77 (95% CI 0.762-0.771) for the normal group, 0.77 (95% CI 0.768-0.772) for the mild group, and 0.85 (95% CI 0.840-0.851) for the severe group, with a slightly lower performance in the external validation. Conclusion. The LSTM demonstrated good discrimination of patients who had deterioration in serum lactate levels. Clinical studies are needed to evaluate whether utilization of a clinical decision support tool based on these results could positively impact decision-making and patient outcomes.

q-bio.QM↗