ODySSeI: An Open-Source End-to-End Framework for Automated Detection, Segmentation, and Severity Estimation of Lesions in Invasive Coronary Angiography Images

Anand Choudhary; Xiaowu Sun; Thabo Mahendiran; Ortal Senouf; Denise Auberson; Bernard De Bruyne; Stephane Fournier; Olivier Muller; Emmanuel Abbé; Pascal Frossard; Dorina Thanou

arXiv · 2603.20021

ODySSeI: An Open-Source End-to-End Framework for Automated Detection, Segmentation, and Severity Estimation of Lesions in Invasive Coronary Angiography Images

Anand Choudhary·Xiaowu Sun·Thabo Mahendiran·Ortal Senouf·Denise Auberson·Bernard De Bruyne·Stephane Fournier·Olivier Muller·Emmanuel Abbé·Pascal Frossard·Dorina Thanou

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Abstract

Invasive Coronary Angiography (ICA) is the clinical gold standard for the assessment of coronary artery disease. However, its interpretation remains subjective and prone to intra- and inter-operator variability. In this work, we introduce ODySSeI: an Open-source end-to-end framework for automated Detection, Segmentation, and Severity estimation of lesions in ICA images. ODySSeI integrates deep learning-based lesion detection and lesion segmentation models trained using a novel Pyramidal Augmentation Scheme (PAS) to enhance robustness and real-time performance across diverse patient cohorts (2149 patients from Europe, North America, and Asia). Furthermore, we propose a quantitative coronary angiography-free Lesion Severity Estimation (LSE) technique that directly computes the Minimum Lumen Diameter (MLD) and diameter stenosis from the predicted lesion geometry. Extensive evaluation on both in-distribution and out-of-distribution clinical datasets demonstrates ODySSeI's strong generalizability. Our PAS yields large performance gains in highly complex tasks as compared to relatively simpler ones, notably, a 2.5-fold increase in lesion detection performance versus a 1-3\% increase in lesion segmentation performance over their respective baselines. Our LSE technique achieves high accuracy, with predicted MLD values differing by only $\pm$ 2-3 pixels from the corresponding ground truths. On average, ODySSeI processes a raw ICA image within only a few seconds on a CPU and in a fraction of a second on a GPU and is available as a plug-and-play web interface at swisscardia.epfl.ch. Overall, this work establishes ODySSeI as a comprehensive and open-source framework which supports automated, reproducible, and scalable ICA analysis for real-time clinical decision-making.

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Anand Choudhary, Xiaowu Sun, Thabo Mahendiran, Ortal Senouf, Denise Auberson, Bernard De Bruyne, Stephane Fournier, Olivier Muller, Emmanuel Abbé, Pascal Frossard, Dorina Thanou. 2026-03-20. ODySSeI: An Open-Source End-to-End Framework for Automated Detection, Segmentation, and Severity Estimation of Lesions in Invasive Coronary Angiography Images. https://arxiv.org/abs/2603.20021

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