Sensitivity analysis for causal mediation: bridge score, sharp sensitivity bounds, and calibration

Abstract

Causal mediation analysis decomposes the total treatment effect into a portion operating through a hypothesized mediator and a residual direct portion. Identification of natural direct and indirect effects typically rests on the mediator stage of sequential ignorability, which cannot be empirically verified and requires explicit sensitivity analysis. We formulate the \emph{bridge score}, a mediator-stage balancing score, as a low-dimensional vector formed from the two treatment-specific mediator densities at a common mediator value, and show that it balances baseline covariates for the mediator stage relevant to natural effect identification. Conditional on the bridge score, we derive a sharp pointwise variance envelope on the unidentified mediator-outcome confounding function in terms of latent outcome relevance and residual selection. To make the bound operational for sensitivity analysis, we further introduce a residual budget calibration approach based on local residual outcome variation and record a complementary range bound for support-based restrictions. Finally, we show how the pointwise bound can be operationalized for inference through a scalar functional reduction and a Bayesian g-computation algorithm that combines observed-data posterior uncertainty with user-specified sensitivity uncertainty, rather than treating the unidentified sensitivity corrections as learned from the likelihood.