On multi-fidelity methods for a tumor growth model with uncertainties

Abstract

We develop a hierarchical multi-fidelity (MF) framework for efficient uncertainty quantification of porous-medium equation (PME) tumor growth models with moving free boundaries. The proposed approach combines coarse-grid PME solvers, level-set approximations of the Hele--Shaw limit, and fine-grid asymptotic-preserving PME discretizations, thereby integrating both discretization-based and asymptotic-model-based fidelity reduction. To guide the selection of high-fidelity samples, we introduce a residual-based farthest-point sampling (RFPS) criterion that combines projection residual information with a distance-based separation term in the low-fidelity snapshot space. Based on this criterion, we construct both bi-fidelity and tri-fidelity approximations, together with empirical error indicators for adaptive refinement. Numerical experiments are conducted in both bi-fidelity and tri-fidelity settings under several uncertainty scenarios, showing that the proposed multi-fidelity approximations achieve accurate results with reduced high-fidelity sampling cost in the reported tests.