Quantitative Multi-Modal Optical Coherence Photoacoustic Elastography

Abstract

We present a novel multi-modal optical coherence photoacoustic elastography framework, which combines two imaging modalities, optical coherence tomography and photoacoustic tomography, to enable complementary absorption-scattering measurements for the extraction of quantitative tissue features via quasi-static elastography. For this, we develop a sophisticated hybrid inversion algorithm for merging the complementary information layers contained in both optical coherence and photoacoustic-based elastography measurements, and perform systematic evaluations to assess the impact of hybrid elastography data on strain and stiffness reconstructions. An extension to a photoacoustic tomography and optical coherence tomography imaging system allows precise elastographic experiments. Studies on a silicone elastomer phantom demonstrate that the combined optical coherence - photoacoustic approach outperforms single-modality optical coherence elastography and photoacoustic elastography, yielding higher strain signal-to-noise ratios and improved stiffness estimates. These results establish the advantage of multi-modal complementary imaging and data merging for accurate, high-resolution elastographic strain and stiffness mapping in both scattering and absorbing materials.