OpenPINT: Open-source Planning for Isoeffective Nuclear Treatments in BNCT research

Ian Postuma; Sara J. González; Setareh Fatemi; Cristina Pezzi; Carolina Ruzzon; Oreste Nicrosini; Valerio Vercesi; Silva Bortolussi

arXiv · 2606.21476

OpenPINT: Open-source Planning for Isoeffective Nuclear Treatments in BNCT research

Ian Postuma·Sara J. González·Setareh Fatemi·Cristina Pezzi·Carolina Ruzzon·Oreste Nicrosini·Valerio Vercesi·Silva Bortolussi

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Abstract

Objective: Present OpenPINT (Open-source Planning for Isoeffective Nuclear Treatments), an open-source treatment planning system for nuclear therapies that integrates Monte Carlo dose calculations with modular dosimetric and radiobiological models for photon-isoeffective dose evaluation. Approach: We describe the software architecture, implementation choices, and data flow from segmented geometry and source configuration to NIfTI dose outputs. We define BNCT-relevant dosimetric metrics and evaluate the workflow with reproducible analytic and voxelized cylindrical-phantom benchmarks, supplemented by a geometric patient-positioning example. Main results: The module provides a reproducible and scriptable path for generating MCNP-ready inputs, extracting component-wise BNCT dose maps, and computing analysis-ready outputs for quality checks and decision support. Fine-resolution voxelized configurations reproduced the 1 mm analytic reference within 0.13% for the brain-limited irradiation-time endpoint, whereas the full voxelized sweep exposed deviations up to 4.42% in coarse 8--10 mm configurations. Patient-wide gamma pass rates were at least 99.60% for the evaluated mesh/interpolation cases, while low-dose DVH-tail quantities remained sensitive to boundary discretization. Significance: This first paper isolates and validates the simulation-preparation and dosimetric-analysis core of an open-source BNCT treatment-planning platform. It establishes a foundation for subsequent work on optimization, biological weighting, and clinical workflow integration.

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Ian Postuma, Sara J. González, Setareh Fatemi, Cristina Pezzi, Carolina Ruzzon, Oreste Nicrosini, Valerio Vercesi, Silva Bortolussi. 2026-06-19. OpenPINT: Open-source Planning for Isoeffective Nuclear Treatments in BNCT research. https://arxiv.org/abs/2606.21476

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