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arXiv · 2607.02200

Free-breathing Pulmonary Relaxometry at 0.55T

Pavlos Panos·Oliver Bieri·Maurice Pradella·Katrin E. Hostettler·Grzegorz Bauman
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Abstract

Purpose: To evaluate the feasibility of an integrated, free-breathing workflow for automated 2D pulmonary relaxometry (T1, T2) at 0.55T. Methods: A 2D inversion recovery ultra-fast balanced steady-state free precession (IR-uf-bSSFP) sequence was adapted to achieve high-temporal sampling of the transient phase at 0.55T. The technique was validated in a phantom and tested in eight healthy volunteers as well as one patient. A fully automated pipeline was developed, featuring multi-contrast registration for motion correction and deep learning based lung segmentation to enable voxel-wise nonlinear fitting for T1 and T2 map generation. Results: Phantom results were in close agreement with reference scans. In-vivo, the proposed free-breathing framework effectively mitigated respiratory motion, yielding quantitative maps in close agreement with breath-hold references. Healthy lung parenchyma relaxation times were T1 = (930+-40)ms and T2 = (90+-8)ms. In a patient case, the method successfully distinguished a solid lung mass from healthy parenchyma, with the lesion showing elevated T1 (960ms vs 810ms in the surrounding parenchyma). Conclusions: Simultaneous free-breathing T1 and T2 mapping of the lung is feasible at 0.55T using a fully automated pipeline. By eliminating breath-holds and external gating, this approach improves patient compliance and potentially facilitates the use of quantitative lung MRI in routine clinical practice.

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Pavlos Panos, Oliver Bieri, Maurice Pradella, Katrin E. Hostettler, Grzegorz Bauman. 2026-07-02. Free-breathing Pulmonary Relaxometry at 0.55T. https://arxiv.org/abs/2607.02200

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