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arXiv · 2608.23472

Evaluating the effects of policy interventions subject to early adoption: A case study of prescription drug monitoring programs and opioid dispensing

Sarika Aggarwal·Brent A. Coull·Nima Hejazi·Rachel C. Nethery
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Abstract

Policies that require organizations to use new systems, such as prescription drug monitoring programs (PDMPs), are often implemented in phases, with an initial period of voluntary access followed by mandated compliance. This allows the policy intervention to be adopted before compliance is required (early adoption), causing outcomes to change before the mandate takes effect. When early adoption is present, the no-anticipation assumption underlying synthetic control methods (SCM) is violated, leading to biased policy effect estimates. We formalize early adoption in a potential outcomes framework for staggered policy implementation and decompose the total policy effect into early adoption and mandate components. We then propose a two-stage, early adoption-aware SCM procedure that first estimates early adoption effects using an interactive fixed effects model fit to pre-mandate data and then residualizes outcomes before applying SCM variants to estimate mandate and total policy effects. Simulations, including settings with correlation between early adoption and latent factors, show reduced bias and improved uncertainty quantification relative to conventional SCM estimators. We apply the framework to state-level PDMP policies and per-capita opioid dispensing. After accounting for early adoption, estimates suggest reductions in opioid dispensing following PDMP availability and mandates; however, the estimates are imprecise and not statistically significant.

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Sarika Aggarwal, Brent A. Coull, Nima Hejazi, Rachel C. Nethery. 2026-08-24. Evaluating the effects of policy interventions subject to early adoption: A case study of prescription drug monitoring programs and opioid dispensing. https://arxiv.org/abs/2608.23472

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