Noise-Resilient Detection of Neuronal Spikes by a Hopf-Bifurcation Device

Abstract

Detecting weak transient signals in noise is a persistent challenge in sensing, communication, and electrophysiology. Here, we demonstrate a physical weak-signal detector based on a semiconductor negative differential resistance (NDR) device operated near a Hopf bifurcation. A coherent input that persists over the response time of the dynamical system can drive a transition between quiescent and oscillatory states, whereas faster stochastic fluctuations are largely suppressed. This nonlinear transformation converts a weak analog threshold crossing into all-or-none voltage spikes and therefore provides asynchronous signal detection without a reference clock. Using a modulated photovoltaic signal, we detect a weak frequency component of 100 Hz as a demonstration, at an input signal-to-noise amplitude ratio as low as 1/500, and reliably recover it in the output spectrum. We then apply the same principle to neuronal multisite extracellular recordings. After standard band-pass filtering, the raw microelectrode signal is transformed by the NDR dynamics, enhancing the distinction between neuronal spikes and background fluctuations. The resulting detected spike times agree closely with those obtained using a traditional spike-detection pipeline. These results establish bifurcation-engineered NDR dynamics as a compact hardware approach to noise-resilient signal discrimination and event-based analog-to-digital conversion that will be useful for neuroprosthetic devices.