Phorecaster365: A Human-Supervised Reference Architecture for Hybrid Pharmaceutical Sales Forecasting and Planning Decision Support

Abstract

Pharmaceutical sales forecasts inform planning across products, regions, and distribution channels, yet their interpretation depends on inventory availability, transaction semantics, product lifecycle, and the information available when each forecast is issued. A model prediction alone does not preserve these conditions or establish whether a forecast is suitable for operational use. We present Phorecaster365, a human-supervised reference architecture that connects enterprise resource planning data to reviewable pharmaceutical sales forecasts. The architecture separates source ingestion, product-region series construction, temporally valid feature generation, statistical and machine-learning modeling, ensemble formation, uncertainty assessment, planner review, and lifecycle governance. Its central intermediate representation is a forecast context package that preserves the source snapshot, forecast target, temporal cutoff, available covariates, data-quality state, and hierarchy version. A corresponding forecast evidence package links predictions to model and calibration versions, exceptions, human adjustments, and publication history. Development experience with a synthetic panel of 10,950 daily records across 30 product-region series informs the design. Historical experiment summaries are retained only as descriptive evidence of development because their evaluation does not establish independent predictive validity. We specify a rolling-origin evaluation protocol, baseline and ablation requirements, uncertainty and robustness assessments, and a staged pathway from synthetic testing to use in governed planning. The contribution is an implementation-neutral system design and validation framework; the report does not establish real-world forecasting accuracy, comparative superiority, or operational benefit.