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Amino acid classes and the protein folding problem

Marek Cieplak·Neal S. Holter·Amos Maritan·Jayanth R. Banavar
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Abstract

We present and implement a distance-based clustering of amino acids within the framework of a statistically derived interaction matrix and show that the resulting groups faithfully reproduce, for well-designed sequences, thermodynamic stability in and kinetic accessibility to the native state. A simple interpretation of the groups is obtained by eigenanalysis of the interaction matrix.

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Marek Cieplak, Neal S. Holter, Amos Maritan, Jayanth R. Banavar. 2000-10-18. Amino acid classes and the protein folding problem. https://doi.org/10.1063/1.1333025

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