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Effect of defects on thermal denaturation of DNA Oligomers

Navin Singh·Yashwant Singh
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Abstract

The effect of defects on the melting profile of short heterogeneous DNA chains are calculated using the Peyrard-Bishop Hamiltonian. The on-site potential on a defect site is represented by a potential which has only the short-range repulsion and the flat part without well of the Morse potential. The stacking energy between the two neigbouring pairs involving a defect site is also modified. The results are found to be in good agreement with the experiments.

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Navin Singh, Yashwant Singh. 2001-08-29. Effect of defects on thermal denaturation of DNA Oligomers. https://doi.org/10.1103/physreve.64.042901

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