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Exact Solution of the Munoz-Eaton Model for Protein Folding

Pierpaolo Bruscolini·Alessandro Pelizzola
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Abstract

A transfer-matrix formalism is introduced to evaluate exactly the partition function of the Munoz-Eaton model, relating the folding kinetics of proteins of known structure to their thermodynamics and topology. This technique can be used for a generic protein, for any choice of the energy and entropy parameters, and in principle allows the model to be used as a first tool to characterize the dynamics of a protein of known native state and equilibrium population. Applications to a $β$-hairpin and to protein CI-2, with comparisons to previous results, are also shown.

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BibTeXRIS

Pierpaolo Bruscolini, Alessandro Pelizzola. 2002-05-30. Exact Solution of the Munoz-Eaton Model for Protein Folding. https://doi.org/10.1103/physrevlett.88.258101

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