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Entropy loss in long-distance DNA looping

Andreas Hanke·Ralf Metzler
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Abstract

The entropy loss due to the formation of one or multiple loops in circular and linear DNA chains is calculated from a scaling approach in the limit of long chain segments. The analytical results allow to obtain a fast estimate for the entropy loss for a given configuration. Numerical values obtained for some examples suggest that the entropy loss encountered in loop closure in typical genetic switches may become a relevant factor which has to be overcome by the released bond energy between the looping contact sites.

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BibTeXRIS

Andreas Hanke, Ralf Metzler. 2002-11-21. Entropy loss in long-distance DNA looping. https://doi.org/10.1016/s0006-3495(03)74463-4

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