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Four-states phase diagram of proteins

Olivier Collet
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Abstract

A four states phase diagram for protein folding as a function of temperature and solvent quality is derived from an improved 2-d lattice model taking into account the temperature dependence of the hydrophobic effect. The phase diagram exhibits native, globule and two coil-type regions. In agreement with experiment, the model reproduces the phase transitions indicative of both warm and cold denaturations. Finally, it predicts transitions between the two coil states and a critical point.

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Olivier Collet. 2005-09-06. Four-states phase diagram of proteins. https://doi.org/10.1209/epl%2Fi2005-10225-9

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