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Denaturation of Heterogeneous DNA

D. Cule·T. Hwa
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Abstract

The effect of heterogeneous sequence composition on the denaturation of double stranded DNA is investigated. The resulting pair-binding energy variation is found to have a negligible effect on the critical properties of the smooth second order melting transition in the simplest (Peyrard-Bishop) model. However, sequence heterogeneity is dramatically amplified upon adopting a more realistic treatment of the backbone stiffness. The model yields features of ``multi-step melting'' similar to those observed in experiments.

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D. Cule, T. Hwa. 1997-07-09. Denaturation of Heterogeneous DNA. https://doi.org/10.1103/physrevlett.79.2375

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