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Stable integration of isolated cell membrane patches in a nanomachined aperture: a step towards a novel device for membrane physiology

N. Fertig·A. Tilke·R. H. Blick·J. P. Kotthaus·J. C. Behrends·G. ten Bruggencate
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Abstract

We investigate the microscopic contact of a cell/semiconductor hybrid. The semiconductor is nanostructured with the aim of single channel recording of ion channels in cell membranes. This approach will overcome many limitations of the classical patch-clamp technique. The integration of silicon-based devices 'on-chip' promises novel types of experiments on single ion channels.

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N. Fertig, A. Tilke, R. H. Blick, J. P. Kotthaus, J. C. Behrends, G. ten Bruggencate. 1999-10-14. Stable integration of isolated cell membrane patches in a nanomachined aperture: a step towards a novel device for membrane physiology. https://arxiv.org/abs/cond-mat/9910217

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