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Analysis of a model for the dynamics of prions II

Hans Engler·Jan Pruess·Glenn F. Webb
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Abstract

A new mathematical model for the dynamics of prion proliferation involving an ordinary differential equation coupled with a partial integro-differential equation is analyzed, continuing earlier work. We show the well-posedness of this problem in a natural phase space, i.e. there is a unique global semiflow in the phase space associated to the problem. A theorem of threshold type is derived for this model which is typical for mathematical epidemics. If a certain combination of kinetic parameters is below or at the threshold, there is a unique steady state, the disease-free equilibrium, which is globally asymptotically stable; above the threshold it is unstable, and there is another unique steady state, the disease equilibrium, which inherits that property.

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Hans Engler, Jan Pruess, Glenn F. Webb. 2005-07-27. Analysis of a model for the dynamics of prions II. https://arxiv.org/abs/math/0507575

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