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Dynamical investigation of macromolecular hybridization bioassays

R. Bittner·M. Wassermeier·A. Wixforth
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Abstract

A novel sensoric technique for the dynamical in situ investigation of a hybridization bio assay is presented, which utilizes a metal bead labeling method. Therein, hybridization results in an increased metal coverage on parts of a substrate, where it takes place. Our sensing principle relies on the measurement of the radio frequency impedance of the hybridization spots. We propose several examples for sensor devices.

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R. Bittner, M. Wassermeier, A. Wixforth. 2002-07-16. Dynamical investigation of macromolecular hybridization bioassays. https://arxiv.org/abs/physics/0207064

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